Among the listed medications, which requires a non-PVC container?

• A. Sulfamethoxazole
• B. Phenytoin
• C. Tacrolimus
• D. Daptomycin

Answer: (C)

Tacrolimus is the medication that requires a non-PVC container due to its susceptibility to leaching of harmful substances from polyvinyl chloride (PVC) materials. Tacrolimus is a calcineurin inhibitor used primarily in organ transplantation and for autoimmune conditions. Its stability can be compromised when stored in PVC containers, which can cause degradation of the medication, resulting in reduced efficacy and potential safety concerns. Therefore, it is crucial to store tacrolimus in containers made of non-PVC materials such as glass or certain types of polyethylene to ensure its integrity and effectiveness.

The other medications listed do not have the same requirement for non-PVC containers. Sulfamethoxazole and daptomycin are commonly stored in standard IV bags which may contain PVC, while phenytoin is generally stable in PVC but does have specific compatibility considerations, making tacrolimus distinct in its need for non-PVC storage. This knowledge is essential for ensuring appropriate handling and administration of medications in a clinical setting.