What does the acronym ANTIMAN VAMP represent regarding key hepatotoxic drugs?

• A. Amiodarone, Nevirapine, Tetracycline
• B. Apap, NRTIs, Tipranavir, Isoniazid
• C. Aspirin, Nevirapine, Metronidazole
• D. Azoles, Naloxone, Tramadol

Answer: (B)

The acronym ANTIMAN VAMP is used to remember key hepatotoxic drugs that can cause liver damage or injury. The choice that correctly fills this mnemonic includes the following components: Acetaminophen (often referred to as APAP), NRTIs (nucleoside reverse transcriptase inhibitors), Tipranavir (an HIV protease inhibitor), and Isoniazid (an antibiotic used to treat tuberculosis).

Acetaminophen is widely recognized for its potential to cause acute liver failure, particularly in cases of overdose. NRTIs, such as zidovudine and lamivudine, can also lead to hepatotoxicity, especially in patients with pre-existing liver conditions or when used in high doses. Tipranavir has been noted to cause liver enzyme elevations and can lead to hepatotoxic events. Isoniazid, used as part of tuberculosis treatment, is notorious for causing liver damage in a minority of patients.

This acronym helps healthcare professionals to remember these drugs, emphasizing the clinical relevance of monitoring liver function in patients taking these medications.