What does the acronym TRAPT BD FN DG stand for in the context of CrCl CI drugs?

• A. Trimethoprim, Rivaroxaban, Avanafil, Potassium sparing diuretics
• B. Tamsulosin, Ranitidine, Amlodipine, Potassium
• C. Telmisartan, Risperidone, Amiodarone, Prednisone
• D. Tramadol ER, Bisphosphonates, Fondaparinux, NSAIDs

Answer: (D)

The acronym TRAPT BD FN DG is a helpful mnemonic used in pharmacology to remember which drugs require dose adjustment in patients with decreased creatinine clearance (CrCl). Understanding this context is crucial for ensuring the safety and effectiveness of medication therapies in patients with impaired renal function.

The correct answer includes Tramadol ER (extended release), Bisphosphonates (such as Alendronate), Fondaparinux, and NSAIDs (non-steroidal anti-inflammatory drugs). Each of these medications can accumulate in the body if renal clearance is compromised, leading to potential toxicity or adverse effects.

Tramadol ER is an opioid analgesic that can lead to respiratory depression if dosages are not adjusted appropriately in patients with renal issues. Bisphosphonates are used to treat osteoporosis and can risk causing renal damage if not dosed correctly in patients with reduced kidney function. Fondaparinux is an anticoagulant that requires careful monitoring and adjustment as its renal clearance is a significant elimination pathway. Lastly, NSAIDs can cause renal function deterioration, and their dosing needs to be adjusted to mitigate the risk of nephrotoxicity.

By correctly identifying these medications, healthcare providers can better manage the treatment plans of patients with compromised renal function to avoid