What is the primary premedication used with Docetaxel?

• A. Dexamethasone
• B. Prednisone
• C. Hydrocortisone
• D. Carbamazepine

Answer: (A)

Dexamethasone is the primary premedication used with Docetaxel primarily to mitigate the risk of fluid retention and hypersensitivity reactions associated with the drug. Docetaxel, a taxane chemotherapy agent, can cause significant side effects, including edema, allergic reactions, and other infusion-related reactions. Dexamethasone, a potent corticosteroid, helps to reduce inflammation and suppress the immune response, which diminishes these risks.

While other corticosteroids, like prednisone and hydrocortisone, have similar properties, dexamethasone is particularly favored due to its longer half-life and more potent anti-inflammatory effects, making it much more effective for premedication in this context. The option involving carbamazepine is unrelated to the premedication regimen for Docetaxel, as carbamazepine serves as an anticonvulsant and is not utilized for this purpose. Hence, dexamethasone is the best choice for ensuring patient safety and comfort during treatment with Docetaxel.