Which drug belongs to the category of GI drugs requiring dose adjustments?

• A. Famotidine
• B. Valproate
• C. Levofloxacin
• D. Sertraline

Answer: (A)

Famotidine is classified as a gastrointestinal (GI) drug primarily used to treat conditions such as peptic ulcers and gastroesophageal reflux disease (GERD). It functions as an H2 receptor antagonist, reducing the production of stomach acid.

Patients with renal impairment may require dose adjustments for famotidine due to its excretion through the kidneys. In cases where renal function is compromised, famotidine can accumulate in the body, potentially leading to increased risk of side effects. Therefore, monitoring renal function and adjusting the dosage of famotidine ensures safe and effective treatment for patients with altered kidney function.

In contrast, while valproate, levofloxacin, and sertraline are important medications in their respective categories, their dose adjustments are primarily based on different factors such as liver function (for valproate) or other specific clinical considerations rather than being solely related to GI effects or common renal considerations associated with gastric acid secretion. Therefore, famotidine stands out as the drug that specifically requires dose adjustments in cases of renal impairment among the choices given.