Which of the following compounds is considered a key hepatotoxic agent?

• A. Clindamycin
• B. Azithromycin
• C. Isoniazid
• D. Fluconazole

Answer: (C)

Isoniazid is considered a key hepatotoxic agent due to its mechanism of action and the metabolic pathways involved in its processing within the liver. This medication is primarily used in the treatment of tuberculosis and is known to be associated with liver damage, particularly in individuals who may have pre-existing liver conditions or those who consume alcohol regularly. The hepatotoxicity of isoniazid can result from the formation of reactive metabolites, which can lead to hepatocyte injury and necrosis. Monitoring liver function tests is essential in patients undergoing treatment with isoniazid to detect any early signs of liver damage, allowing for timely intervention.

Other agents listed may have side effects, but they are not prominently associated with hepatotoxicity to the extent of isoniazid. Therefore, understanding the specific risk profiles of these medications is crucial for pharmacists and healthcare providers in managing patients who require treatment with these drugs.