Which of the following drugs should not be filtered during preparation?

• A. Amiodarone
• B. Taxanes
• C. Phenytoin
• D. Lipids

Answer: (C)

Phenytoin should not be filtered during preparation due to its particular formulation characteristics. It is formulated as an oil-in-water emulsion, which can lead to the formation of particulate matter or aggregation when subjected to filtration. Additionally, the use of filters may strip away the necessary components of phenytoin and alter its effectiveness.

In contrast, other options like amiodarone, taxanes, and lipids are commonly filtered during preparation. Amiodarone may require filtration to remove potential particulate contaminants before administration. Taxanes, being chemotherapy agents, also have strict preparation and administration guidelines that often include filtering to ensure the safety and efficacy of the drug. Lipids, especially in parenteral nutrition, can be filtered to remove particulate matter and prevent complications during intravenous administration. Therefore, phenytoin stands out as the drug that should not be filtered due to its unique properties and the risk of compromising its formulation and therapeutic efficacy.