Which of the following is NOT included in the ADAPT BC mnemonic related to drugs that may increase potassium?

• A. Canagliflozin
• B. Drospirenone
• C. Metformin
• D. Tacrolimus

Answer: (C)

The ADAPT BC mnemonic is a systematic way to remember specific medications that are known to potentially increase potassium levels in the body. Each letter typically corresponds to a category of drugs or specific drug that affects potassium regulation.

In this case, metformin is not included in the ADAPT BC mnemonic because it is not typically associated with causing hyperkalemia or significant increases in potassium levels. Metformin is primarily used for managing type 2 diabetes and primarily works by improving insulin sensitivity and decreasing hepatic glucose production, without having a direct impact on potassium levels.

The other options, such as canagliflozin, drospirenone, and tacrolimus, are all known to have the potential to raise potassium. Canagliflozin is an SGLT2 inhibitor that can affect renal function, thereby influencing potassium levels. Drospirenone, a progestin, has potassium-sparing properties that can lead to increased serum potassium. Tacrolimus, an immunosuppressant used in organ transplantation, is associated with hyperkalemia, especially in patients with renal impairment.

Understanding which medications are included in the ADAPT BC mnemonic can help healthcare professionals monitor and manage potassium levels more effectively, avoiding complications associated with hyperkalemia.