Which of the following is a drug used for migraine prophylaxis?

• A. Valproate
• B. Carbamazepine
• C. Topiramate
• D. Both Valproate and Topiramate

Answer: (D)

Valproate and Topiramate are both effective agents used for migraine prophylaxis. Valproate, a type of anticonvulsant, is utilized for its efficacy in reducing the frequency and severity of migraine attacks. It works by stabilizing neuronal membranes and inhibiting excitatory neurotransmission. Similarly, Topiramate also serves as an anticonvulsant and has been shown to decrease migraine occurrences by targeting various pathways, including those involved in neurotransmitter balance.

Both medications are recognized and commonly used in clinical practice for the long-term management of migraine, making the option that includes both drugs the most comprehensive and correct choice. While Carbamazepine is an anticonvulsant used for various types of seizures and some types of neuropathic pain, it is not typically indicated for migraine prophylaxis.